CPDM's Collection of Pediatric Tumor PDX and Spheroid Models
CPDM has a unique collection of pediatric brain and hematologic tumor models available for research. These pediatric models have been previously used in various studies, including Cancer Cell. 2016, Cancer Res. 2018, and Nat Commun. 2019, and a selected set will be characterized in the Cancer Dependency Map Project.
See our detailed model lists for more information about our pediatric tumor models. RNA-seq data, whole-exome seq data, and low-pass WGS data are available on cBioPortal. Genomic and transcriptomic data for these models is also available.
Learn more about ordering and licensing these models, or email us at models@dfci.harvard.edu to submit an inquiry.
See CPDM's SOPs for working with these models for guidance.
| Organ Site | Summarized Diagnosis | # of Models |
|---|---|---|
| Brain | Glioblastoma_IDH_wildtype_4 | 8 |
| Brain | Medulloblastoma_4 | 8 |
| Brain | Anaplastic_Astrocytoma_NOS | 3 |
| Brain | Pineoblastoma_4 | 2 |
| Brain | Anaplastic_Ependymoma_3 | 1 |
| Brain | Atypical Teratoid/Rhabdoid Tumor | 1 |
| Brain | Diffuse_Midline_Glioma_NOS | 1 |
| Brain | Glioblastoma_IDH_Mutant_4 | 1 |
| Brain | Glioblastoma_NOS_4 | 1 |
| Brain | High_Grade_Glioma_NOS | 1 |
| Brain | Meningioma_Anaplastic_3 | 1 |
| Hematologic | B-Cell Acute Lymphoblastic Leukemia | 30 |
| Hematologic | Acute Monocytic Leukemia | 3 |
| Hematologic | Acute Myeloid Leukemia | 2 |
| Hematologic | T-Cell Acute Lymphoblastic Leukemia | 2 |
| Hematologic | Acute Lymphoid Leukemia | 1 |
| Other Tumor | Wilms Tumor | 18 |
| Other Tumor | Alveolar Rhabdomyosarcoma | 6 |
| Other Tumor | Ewing Sarcoma | 3 |
| Other Tumor | Neuroblastoma | 3 |
| Other Tumor | Mesoblastic Nephroma | 2 |
| Other Tumor | Osteosarcoma | 2 |
| Other Tumor | Adrenal Cortical Carcinoma | 1 |
| Other Tumor | Angiosarcoma | 1 |
| Other Tumor | Congenital/Infantile Rhabdomyosarcoma | 1 |
| Other Tumor | Embryonal Rhabdomyosarcoma | 1 |
| Other Tumor | Epithelioid Sarcoma | 1 |
| Other Tumor | Gastrointestinal Stromal Tumor | 1 |
| Other Tumor | Hepatoblastoma | 1 |
| Other Tumor | Malignant Peripheral Nerve Sheath Tumor | 1 |
| Other Tumor | Renal Medullary Carcinoma | 1 |
| Other Tumor | Rhabdomyosarcoma | 1 |
| Other Tumor | Spindle Cell Sarcoma | 1 |
| Other Tumor | Undifferentiated Sarcoma | 1 |