In This Issue
- Introduction by Joseph Antin, MD - One of the major challenges in the past 40 years of stem cell transplantation has been donor availability.
- Clinical Practice Spotlight: Management of Graft-versus-Host Disease (GVHD) - Risk factors for GVHD include greater degree of HLA mismatch between donor and recipient; stem cell source (the risk of GVHD with peripheral blood stem cells is greater than with bone marrow stem cells, which is, in turn, greater than with umbilical cord blood); gender mismatch with the donor; multiparity of a female donor; and more intensive conditioning regimens.
- Clinical Trial Spotlight: Bortezomib-Based GVHD Prophylaxis - Allogeneic hematopoietic stem cell transplantation (HSCT) represents a potentially curative option for patients with advanced or aggressive hematologic malignancies.
- Complex Case Study: Four Stem Cell Transplants for Acute Myeloid Leukemia (AML) - In 2003, a then-48-year-old woman who is an avid distance runner presented to her primary care physician after noticing unusual fatigue during a 10-kilometer race.
- Complex Case Study: The Patient's Perspective - While running the Saint Patrick's Road Race on March 22, 2003, near my home in western Massachusetts, I could hardly catch my breath.
- Research Spotlight: Transformation of Hematopoietic Cell Transplantation from Stem to Stern - For patients with active, advanced acute myeloid leukemia (AML) and chronic lymphoid leukemia (CLL) who are undergoing HSCT.
Additional Resources
Hematologic Oncology Treatment Center
Clinical Trials for Hematologic Malignancies
Older Adult Hematologic Malignancy Program