Models for Immuno-Oncology
CPDM has a collection of PDX/PDCL models that have patient-matched PBMCs (peripheral blood mononuclear cells) available. We have ongoing efforts to collect patient-matched PBMCs for the new cancer models that we are generating, and to make modification on the patient-matched immune cells amendable for immuno-oncology studies.
The cell line and xenograft models can be co-cultured with activated immune cells from PBMCs in various cell-based assays. Patient derived serum preparation is also available to be paired with these cell-based assays.
We are interested in partnering with academia and industry collaborators to develop studies around this exciting collection of cancer models and PBMCs.
The following summarizes the cancer models for which we have patient-matching PBMCs:
| CPDM ID | Model Type | Summarized Diagnosis |
|---|---|---|
| CPDM_0813X | PDCL | Anaplastic Oligodendroglioma IDH mutant and 1p 19q codeleted 3 |
| CPDM_0618X | PDCL | Glioblastoma IDH Mutant 4 |
| CPDM_0670X | PDCL | Glioblastoma IDH wildtype 4 |
| CPDM_1705X | PDCL | Glioblastoma IDH wildtype 4 |
| CPDM_1818X | PDCL | Glioblastoma IDH wildtype 4 |
| CPDM_0021X | PDCL | Glioblastoma IDH wildtype 4 |
| CPDM_0051X | PDCL, PDX | Glioblastoma IDH wildtype 4 |
| CPDM_1265X | PDCL, PDX | Glioblastoma IDH wildtype 4 |
| CPDM_1253X | PDX | Glioblastoma IDH wildtype 4 |
| CPDM_1700X | PDX | Lymphoma CNS |
| CPDM_1449X | PDCL | Lymphoma CNS Secondary |
| CPDM_1745X | PDX | Lymphoma CNS Secondary |
| CPDM_0832X | PDX | Lymphoma CNS Secondary |
| CPDM_1359X | PDCL | Metastasis Breast |
| CPDM_1362X | PDCL | Metastasis Breast |
| CPDM_0085X | PDCL | Metastasis Breast |
| CPDM_1404X | PDCL | Metastasis Breast |
| CPDM_0590X | PDX | Metastasis Breast |
| CPDM_1488X | PDX | Metastasis Breast |
| CPDM_1679X | PDCL | Metastasis Colon |
| CPDM_0791X | PDX | Metastasis Colon |
| CPDM_0839X | PDX | Metastasis Colon |
| CPDM_0822X | PDCL | Metastasis Kidney |
| CPDM_0687X | PDCL | Metastasis Kidney |
| CPDM_0046X | PDCL | Metastasis Lung |
| CPDM_0592X | PDCL, PDX | Metastasis Lung |
| CPDM_0084X | PDX | Metastasis Lung |
| CPDM_0672X | PDCL | Metastasis Melanoma |
| CPDM_0840X | PDCL | Metastasis Melanoma |
| CPDM_1237X | PDCL | Metastasis Melanoma |
| CPDM_1645X | PDCL | Metastasis Melanoma |
| CPDM_1726X | PDCL | Metastasis Melanoma |
| CPDM_0025X | PDCL | Metastasis Melanoma |
| CPDM_1277X | PDCL | Metastasis Melanoma |
| CPDM_1216X | PDCL, PDX | Metastasis Melanoma |
| CPDM_0060X | PDCL | Metastasis Ovary |
| CPDM_0780X | PDX | Metastasis Ovary |
| CPDM_1622X | PDX | Metastasis Pancreas |
| CPDM_0783X | PDX | Metastasis Yolk Sac Tumor |
Please email us at models@dfci.harvard.edu for more information.