Rizwan Haq, MD, PhD

A phase I/II study of LY3022855 with BRAF/MEK inhibition in patients with Melanoma. Invest New Drugs. 2023 08; 41(4):551-555. View in: Pubmed

Integrative clinical and molecular characterization of translocation renal cell carcinoma. Cell Rep. 2022 01 04; 38(1):110190. View in: Pubmed

Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial. J Immunother Cancer. 2021 11; 9(11). View in: Pubmed

Long-term Overall Survival and Predictors in Anti-PD-1-naive Melanoma Patients With Brain Metastases Treated With Immune Checkpoint Inhibitors in the Real-world Setting: A Multicohort Study. J Immunother. 2021 10 01; 44(8):307-318. View in: Pubmed

Characterization of genetics in patients with mucosal melanoma treated with immune checkpoint blockade. Cancer Med. 2021 04; 10(8):2627-2635. View in: Pubmed

Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma. Cancer Cell. 2021 05 10; 39(5):649-661.e5. View in: Pubmed

Cytokine changes during immune-related adverse events and corticosteroid treatment in melanoma patients receiving immune checkpoint inhibitors. Cancer Immunol Immunother. 2021 Aug; 70(8):2209-2221. View in: Pubmed

Integrated molecular drivers coordinate biological and clinical states in melanoma. Nat Genet. 2020 12; 52(12):1373-1383. View in: Pubmed

Clinical landscape of oncolytic virus research in 2020. J Immunother Cancer. 2020 10; 8(2). View in: Pubmed

Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nat Med. 2020 Aug; 26(8):1307. View in: Pubmed

Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor-induced colitis. Cancer. 2020 08 15; 126(16):3758-3767. View in: Pubmed

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nat Med. 2020 05; 26(5):792-802. View in: Pubmed

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade. Cancer Discov. 2020 09; 10(9):1296-1311. View in: Pubmed

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020 01 13; 37(1):104-122.e12. View in: Pubmed

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. Nat Struct Mol Biol. 2020 01; 27(1):92-104. View in: Pubmed

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies. Nat Commun. 2019 11 14; 10(1):5157. View in: Pubmed

Complex inter-relationship of body mass index, gender and serum creatinine on survival: exploring the obesity paradox in melanoma patients treated with checkpoint inhibition. J Immunother Cancer. 2019 03 29; 7(1):89. View in: Pubmed

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 11 01; 175(4):984-997.e24. View in: Pubmed

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. Nat Genet. 2018 09; 50(9):1271-1281. View in: Pubmed

Trapping Cancers as They Adapt to Survive. Cancer Discov. 2017 11; 7(11):1216-1217. View in: Pubmed

Characterization of Thyroid Disorders in Patients Receiving Immune Checkpoint Inhibition Therapy. Cancer Immunol Res. 2017 12; 5(12):1133-1140. View in: Pubmed

Point of care assessment of melanoma tumor signaling and metastatic burden from µNMR analysis of tumor fine needle aspirates and peripheral blood. Nanomedicine. 2017 04; 13(3):821-828. View in: Pubmed

Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics. PLoS One. 2014; 9(7):e101286. View in: Pubmed

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discov. 2014 Jul; 4(7):816-27. View in: Pubmed

Metabolic dysregulation in melanoma: cause or consequence? Cancer Discov. 2014 Apr; 4(4):390-1. View in: Pubmed

Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation. Clin Cancer Res. 2014 May 01; 20(9):2257-63. View in: Pubmed

Improving apoptotic responses to targeted therapy. Oncotarget. 2013 Sep; 4(9):1331. View in: Pubmed

Targeting melanoma by small molecules: challenges ahead. Pigment Cell Melanoma Res. 2013 Jul; 26(4):464-9. View in: Pubmed

Oncogenic BRAF regulates oxidative metabolism via PGC1a and MITF. Cancer Cell. 2013 Mar 18; 23(3):302-15. View in: Pubmed

BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4321-6. View in: Pubmed

PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013 Jan 10; 49(1):145-57. View in: Pubmed

YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012; 8(5):e1002688. View in: Pubmed

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature. 2011 Nov 13; 480(7375):99-103. View in: Pubmed

Antitussive and toxicological evaluation of Vitex negundo. Nat Prod Res. 2012; 26(5):484-8. View in: Pubmed

Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer. J Clin Oncol. 2011 Sep 01; 29(25):3474-82. View in: Pubmed

Investigation of antitussive and toxicological activity of Ballota limbata in mice. Pharm Biol. 2011 Jun; 49(6):627-32. View in: Pubmed

Monoamines block kainate- and carbachol-induced gamma-oscillations but augment stimulus-induced gamma-oscillations in rat hippocampus in vitro. Hippocampus. 2009 Mar; 19(3):273-88. View in: Pubmed

A dish best served hot. Am J Med. 2006 Apr; 119(4):307-9. View in: Pubmed

c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 2006 Apr 14; 281(15):10365-73. View in: Pubmed

Age-old theories die hard. Clin Invest Med. 2003 Jun; 26(3):116-20. View in: Pubmed

Chronic inflammatory demyelinating polyradiculoneuropathy in diabetic patients. Muscle Nerve. 2003 Apr; 27(4):465-70. View in: Pubmed

Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res. 2002 Sep 01; 62(17):5076-82. View in: Pubmed

TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways. Blood. 2002 Aug 15; 100(4):1438-48. View in: Pubmed

Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases. J Biol Chem. 2002 May 10; 277(19):17359-66. View in: Pubmed

NKIATRE is a novel conserved cdc2-related kinase. Genomics. 2001 Jan 15; 71(2):131-41. View in: Pubmed

Chronic inflammatory demyelinating polyradiculoneuropathy: a study of proposed electrodiagnostic and histologic criteria. Arch Neurol. 2000 Dec; 57(12):1745-50. View in: Pubmed

Escherichia coli Shiga toxins induce apoptosis in epithelial cells that is regulated by the Bcl-2 family. Am J Physiol Gastrointest Liver Physiol. 2000 May; 278(5):G811-9. View in: Pubmed

Mitoxantrone-DHAP with GM-CSF: an active but myelosuppressive salvage therapy for relapsed/refractory aggressive non-Hodgkin's lymphoma. Leuk Lymphoma. 1999 Nov; 35(5-6):527-36. View in: Pubmed

Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion. Cancer Res. 1999 Aug 15; 59(16):4069-74. View in: Pubmed

Respiratory muscle involvement in Bethlem myopathy. Neurology. 1999 Jan 01; 52(1):174-6. View in: Pubmed

Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance. Cancer Metastasis Rev. 1998 Jun; 17(2):233-9. View in: Pubmed